Indexed on: 28 Jul '16Published on: 28 Jul '16Published in: Langmuir
Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid-glucose complexation. The ratio of boronic acid and glucose functional groups are critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to the to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. To our knowledge, the hydrogel reported here is the first injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose a single component polymeric material.