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Inhibition Mechanism of Novel Pyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives Against Proliferation of A549 and H322 Cancer Cells

Research paper by Jin-hui Shao, Gui-hua Feng

Indexed on: 14 Mar '16Published on: 07 Jan '16Published in: Chinese Medical Sciences Journal



Abstract

To explore the inhibition mechanism and safety of pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives against proliferation of human lung cancer A549 cells, H322 cells, and human umbilical vein endothelial cell (HUVEC).