Indexed on: 01 Sep '78Published on: 01 Sep '78Published in: European Journal of Pediatrics
Heterozygotes for phenylketonuria and controls were given oral loads of 100 mg and 200 mg L-phenylalanine per kilogram body weight. The concentrations of urinary aromatic acids were determined by gas-chromatography after isolation by ion-exchange chromatography and ethylacetate extraction. On an intake of 100 mg L-phenylalanine per kilogram, controls and carriers of classical phenylketonuria excreted nearly the same amounts of aromatic acids (P>0.05). However on an intake of 200 mg per kilogram L-phenylalanine they could be distinguished from one another (P<0.001).