Influence of a multi-strain probiotic on body composition and mood in female occupational shift-workers.

Research paper by Abbie E AE Smith-Ryan, Meredith G MG Mock, Eric T ET Trexler, Katie R KR Hirsch, Malia N M MNM Blue

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme


The present study sought to investigate the effects of a multi-strain probiotic on body composition, regional adiposity, and a series of associated metabolic health outcomes. Female healthcare workers employed on a rotating-shift schedule (n=41) completed baseline anthropometric assessments, a fasted blood draw, questionnaires to assess anxiety, depression (HADS) and fatigue (Chalder Fatigue Survey), and an exercise fatigue test. Identical post-tests occurred following six weeks daily supplementation with placebo (PLA) or probiotics [(2.5 × 109 cfu/g) containing nine bacterial strains (PRO; Ecologic® Barrier) combined with a prebiotic carrier matrix. PRO attenuated fat mass increases (Δ0.14; CI: -0.46-0.75kg) compared to PLA (Δ0.79 kg; CI: 0.03-1.54 kg), while modest reductions in visceral adiposity (VAT) resulted for both PRO and PLA. Metabolic biomarkers (total cholesterol, HDL, glucose, adiponectin, c-reactive protein, IL-6, leptin) were not influenced by either treatment (p>0.05). Non-significant, but potentially clinically relevant improvements in anxiety [change (Δ): -2.3 ± 2.63] and fatigue (Δ: -4.8 ± 5.5) were observed with PRO; exercise performance was unaffected. Results indicate a potential protective effect of PRO against fat mass gain and may alleviate anxiety and fatigue in shift-working females.