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Inference of DNA sequences from mechanical unzipping: an ideal-case study.

Research paper by V V Baldazzi, S S Cocco, E E Marinari, R R Monasson

Indexed on: 12 Apr '06Published on: 12 Apr '06Published in: Physical review letters



Abstract

The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.