Infection associated hemophagocytic lymphohistiocytosis: a report of three cases

Research paper by Magesh Kumar, Dharmesh ., D. B. Santra, Chirag Jain

Indexed on: 27 Dec '20Published on: 23 Dec '20Published in: International Journal of Contemporary Pediatrics


HLH (Hemophagocytic lymphohistiocytosis) is not an uncommon disorder; it is an overreaction of the immune system. It can be familial or acquired and both share one common feature of a highly stimulated and ineffective immune response. Acquired HLH is commonly seen with infection (infection associated hemophagocytic syndrome-IAHS); malignancies and rheumatic disease where it is also known as (macrophage activating syndrome). Here we are reporting three cases of secondary HLH associated with dengue, typhoid and vivax malaria.