Immunoreactive luliberin in the visceral organs of rats

Research paper by V. A. Isachenkov, G. Ya. Bakalkin, V. V. Tsibezov

Indexed on: 01 May '79Published on: 01 May '79Published in: Bulletin of Experimental Biology and Medicine


The distribution of luliberin (luteinizing hormone-releasing hormone, LH-RH) in various organs and tissues of rats was investigated. In the liver, kidneys, duodenum, pancreas, adrenals, and heart of rats a factor analogous to LH-RH in its immunochemical and chromatographic properties was found. The concentration of immunoreactive LH-RH in the liver, kidneys, duodenum, pancreas, and adrenals was about equal (5–7 pg/mg methanol extract obtained from an acetate extract of acetone powder), whereas in the heart it was a little less (2 pg/mg extract). In the blood cells this factor was present in trace amounts. The immunoreactive LH-RH of the visceral organs is either hypothalamic in origin or is synthesized in these organs.