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Immunological studies in patients with central nervous system tumors

Research paper by L. Palmas, Viviana Moschese, Elena Galli, Concetta Barbieri, V. R. M. Lombardi, P. Rossi

Indexed on: 01 Mar '87Published on: 01 Mar '87Published in: Journal of Neuro-Oncology



Abstract

Impairment of cell-mediated immunity in patients with primary central nervous system (CNS) tumors has repeatedly been reported but data to demonstrate the undelying immunological defect are not univocal. This report concerns a series of 31 patients harboring a glioma in which we studied:peripheral blood Tlymphocyte subpopulations by monoclonal antibody analysis;cellular responsiveness to mitogensserum immunoglobulin values.The same parameters were also evaluated in 7 cases of intracranial meningioma and in 8 patients affected by non-proliferative, non-inflammatory CNS diseases. Thirty age-matched healthy volunteers formed the control group.Neither impairment of Tcells as regard to number, responsiveness and subsets, nor abnormal Ig values were found in these groups. However two patients, harboring respectively a third ventricle low grade astrocytoma and an anterior callosal glioblastoma, presented a striking Tcells impairment. These findings might suggest a correlation between hypothalamus and immune system, as already postulated by several previous experimental and clinical studies.