Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts.

Research paper by Maiara M de Moraes, Pedro Carlos PC da Rocha Neto, Felipe Rodrigues FR de Matos, Maria Luiza Diniz de Sousa ML Lopes, Paulo Roberto Medeiros PR de Azevedo, Antonio de Lisboa Lopes Ade L Costa

Indexed on: 22 Jul '14Published on: 22 Jul '14Published in: Journal of Endodontics


The aim of this study was to evaluate and compare the immunohistochemical expression of transforming growing factor beta (TGF-β) and interferon gamma (IFN-γ) between radicular cysts (RCs) and dentigerous cysts (DCs).Twenty RCs and DCs were selected for analysis of the immunoexpression of TGF-β and IFN-γ in the epithelium and capsule.The cell reactivity of TGF-β and IFN-γ in the lining epithelium and capsule of RCs showed no significant differences when compared with DCs (P > .05). There was a tendency of a higher expression of TGF-β in the capsule of DCs.Our results showed the presence of TGF-β and IFN-γ in RCs and DCs, supporting the hypothesis that both participate in the development of these lesions, where IFN-γ usually plays a role in bone resorption, which is counterbalanced by the osteoprotective activity performed by TGF-β.

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