Immune cell interplay in colorectal cancer prognosis.

Research paper by Samuel E SE Norton, Kirsten A KA Ward-Hartstonge, Edward S ES Taylor, Roslyn A RA Kemp

Indexed on: 21 Oct '15Published on: 21 Oct '15Published in: World journal of gastrointestinal oncology


The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.