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IL-6 pathway upregulation in subgroup of severe asthma is associated with neutrophilia and poor lung function.

Research paper by Nil N Turan, Matthew J MJ Edwards, Stewart S Bates, Dominick D Shaw, K F KF Chung, Matthew J MJ Loza, Anna A James, Antoon A Van Oosterhout,

Indexed on: 10 Jan '18Published on: 10 Jan '18Published in: Clinical & Experimental Allergy



Abstract

We have investigated the IL-6 pathway in the severe asthma phenotypes using U-BIOPRED database. A subset of severe asthma patients has increased IL6R mRNA levels and IL-6 protein levels in the sputum. This sub-population is highly neutrophilic and has poorer lung function. These neutrophilic patients have a high unmet medical need and they could potentially benefit from therapy targeting IL-6. This article is protected by copyright. All rights reserved.