Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.

Research paper by Anil A Vasudevan, Matthew J MJ LaMarche, Christopher C Blackburn, Jennifer Lee JL Che, Courtney A CA Luchaco-Cullis, Sujen S Lai, Thomas H TH Marsilje, Michael A MA Patane, Andrew J AJ Souers, Derek D Wodka, Bradley B Geddes, Sumiao S Chen, Seven S Brodjian, Doug H DH Falls, Brian D BD Dayton, et al.

Indexed on: 09 Aug '05Published on: 09 Aug '05Published in: Bioorganic & Medicinal Chemistry Letters


Several potent and efficacious MCHr1 antagonists containing an ortho-amino benzamide or nicotinamide chemotype have been identified, exemplified by 28 and 50.