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Identification of four new susceptibility loci for testicular germ cell tumour

Research paper by Kevin Litchfield, Amy Holroyd, Amy Lloyd, Peter Broderick, Jérémie Nsengimana, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, D. Timothy Bishop, Alison Reid, Robert A. Huddart, Tom Grotmol, Fredrik Wiklund, Janet Shipley, Richard S. Houlston, et al.

Indexed on: 28 Oct '15Published on: 27 Oct '15Published in: Nature Communications



Abstract

Genome-wide association studies (GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygenic model of disease susceptibility strongly influenced by common variation. To identify additional single-nucleotide polymorphisms (SNPs) associated with TGCT, we conducted a multistage GWAS with a combined data set of >25,000 individuals (6,059 cases and 19,094 controls). We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10−9), 11q14.1 (rs7107174, GAB2, P=9.7 × 10−11), 16p13.13 (rs4561483, GSPT1, P=1.6 × 10−8) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10−9). We additionally present detailed functional analysis of these loci, identifying a statistically significant relationship between rs4561483 risk genotype and increased GSPT1 expression in TGCT patient samples. These findings provide additional support for a polygenic model of TGCT risk and further insight into the biological basis of disease development.

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