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Identification of cis-acting regions that contribute to neuron-specific expression of the GAP-43 gene.

Research paper by Mikio M Takahashi, Yoshitaka Y Sato, Yuki Y Nakagami, Katsuhide K Miyake, Shinji S Iijima

Indexed on: 24 Jun '06Published on: 24 Jun '06Published in: Bioscience, biotechnology, and biochemistry



Abstract

There are two transcription start sites in the growth-associated protein 43 (GAP-43) promoter, and several repressive elements have been reported in the control region. But the repressive effects have been analyzed only for the distal transcription start site. Among the repressive elements reported, we found that modulator I repressed GAP-43 gene expression from the proximal promoter in non-neuronal cells. We also found a novel stimulative element immediately downstream of modulator I.