Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor.

Research paper by Sally S Fujiyama-Nakamura, Kaoru K Yamagata, Shigeaki S Kato

Indexed on: 15 Jul '11Published on: 15 Jul '11Published in: Advances in experimental medicine and biology


The maturation of primary microrRNAs (pri-miRNAs) to precursor miRNAs (pre-miRNAs) is mediated by the "microprocessor" complex minimally comprimising two core components, Drosha and DGCR8. However, the roles of RNA-binding proteins associated with these core units in the large Drosha complex remain to be defined. While signal-dependent regulation of miRNA biogenesis is assumed, such regulation remains to be described. here, we provide a short review based on our recent findings of hormonally-regulated pri-miRNA processing by nuclear estrogen receptor.