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Homologues of isomeric dideoxynucleosides as potential antiviral agents: synthesis of isodideoxynucleosides with a furanethanol sugar moiety.

Research paper by X X Zheng, V V Nair

Indexed on: 05 Nov '99Published on: 05 Nov '99Published in: Nucleosides & nucleotides



Abstract

The synthesis of a homologues series of compounds related to (R, S)-isodideoxynucleosides has been completed by coupling a variety of natural purine and pyrimidine bases with a modified sugar intermediate. This sugar precursor was prepared regiospecifically and stereospecifically from D-glucose.