Highly diastereoselective synthesis of enantiopure β-trifluoromethyl β-amino alcohols from chiral trifluoromethyl oxazolidines (Fox).

Research paper by Julien J Simon, Evelyne E Chelain, Thierry T Brigaud

Indexed on: 24 Dec '11Published on: 24 Dec '11Published in: Organic Letters


The organolithium species addition to 2-hydroxymethyl fluorinated oxazolidines (Fox) provides a highly diastereoselective and straightforward route for the synthesis of enantiopure trifluoromethyl β-amino alcohols quaternarized at the β-position.