High magnetic relaxivity in a fluorescent CdSe/CdS/ZnS quantum dot functionalized with MRI contrast molecules.

Research paper by S G SG McAdams, D J DJ Lewis, P D PD McNaughter, E A EA Lewis, S J SJ Haigh, P P O'Brien, F F Tuna

Indexed on: 23 Aug '17Published on: 23 Aug '17Published in: Chemical Communications


Light emitting semiconducting quantum dots show great promise as solar cells, optoelectronic devices and multimodal imaging probes. Here we demonstrate successful grafting of a thiol-functionalised Gd(III) MRI contrast agent onto the surface of core-multishell CdSe/CdS/ZnS quantum dots. The resulting nanoprobe exhibits intense photoluminescence and unprecedentedly large T1 relaxivity of 6800 mM(-1) s(-1) per nanoparticle due to secure implanting of ca. 620 magnetic centers per quantum dot unit.