High-density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti-atherogenic strategy.

Research paper by S-H SH Wang, S-G SG Yuan, D-Q DQ Peng, S-P SP Zhao

Indexed on: 12 Jan '10Published on: 12 Jan '10Published in: Clinical & Experimental Immunology


Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high-density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A-I (apoA-I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol-rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti-atherogenic strategy.