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HIF1A rs10873142 polymorphism is associated with risk of chronic obstructive pulmonary disease in a Chinese Han population: a case-control study.

Research paper by Licheng L Wang, Yaliang Y Tang, Ye Y Chen

Indexed on: 18 Jan '18Published on: 18 Jan '18Published in: Bioscience Reports



Abstract

Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow. Recently, variants in the hypoxia-inducible factor 1α ( HIF1A ) gene were found to be associated with COPD risk. This study aimed to identify whether rs10873142 polymorphism (an intronic polymorphism) in HIF1A gene was related to COPD in a Chinese population. We genotyped HIF1A gene rs10873142 polymorphism in a case-control study with 235 COPD cases and 548 controls in a Chinese Han population. Odd ratios and 95% confidence intervals were estimated using the chi-squared (χ2) test, genetic model analysis, and stratification analysis. In the genetic model analysis, we found that the TT genotype (TT vs CC: OR 1.63; 95% CI, 1.02-2.60; P = 0.042) and T allele (T VS C: OR 1.29; 95%CI, 1.02-1.60; P = 0.032) showed significantly correlation with the risk of COPD. However, in stratification analyses of Age, BMI, and FEV1/FEV, we failed to find any association between HIF1A gene rs10873142 polymorphism with COPD risk. This study supports that HIF1A gene rs10873142 polymorphism may be associated with increased risk of COPD in a Chinese Han population. To the best of our knowledge, this is the first case-control study uncovering that the HIF1A gene rs10873142 polymorphism increases the risk of COPD in a Chinese Han population.