Hepatocellular carcinoma presenting as a precocious cutaneous metastasis.

Research paper by Michael C MC Royer, Walter L WL Rush, George P GP Lupton

Indexed on: 24 Jan '08Published on: 24 Jan '08Published in: The American Journal of dermatopathology


The authors report a case of hepatocellular carcinoma (HCC) diagnosed by evaluation of a cutaneous metastasis in a patient without a prior diagnosis of HCC. Subsequent evaluation confirmed the presence of additional widespread metastatic disease. The medical literature is reviewed with regards to cutaneous metastasis, including precocious metastasis, of HCC. The pathologic evaluation of HCC is reviewed, including a discussion of the immunohistochemical profile of this malignancy and the utility of hepatocyte paraffin 1, CD10, and polyclonal carcinoembryonic antigen (pCEA) immunohistochemical stains.