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Hepatoblastoma with precocious puberty

Research paper by Enono Yhoshu, Yasir A Lone, Jai K Mahajan, Umesh Bahadur Singh

Indexed on: 21 Dec '18Published on: 19 Dec '18Published in: Journal of Indian Association of Pediatric Surgeons



Abstract

Enono Yhoshu, Yasir A Lone, Jai K Mahajan, Umesh Bahadur Singh Journal of Indian Association of Pediatric Surgeons 2019 24(1):68-71 Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.