Hepatitis a virus infection-associated hemophagocytic lymphohistiocytosis in two children.

Research paper by Kirubakaran K Navamani, Manivachagan Muthappa MM Natarajan, Arul Premanand AP Lionel, Sathish S Kumar

Indexed on: 22 Oct '14Published on: 22 Oct '14Published in: Indian Journal of Hematology and Blood Transfusion


Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by high fever, maculopapular rash, neurological symptoms, abnormal liver functions and coagulopathy. Primary HLH is due to an underlying genetic abnormality. Secondary HLH are due to an underlying infection, autoimmune disease or malignancy. Secondary HLH due to viral infections are commonly due to the herpes group commonest of which is the Ebstein Barr virus (EBV). We describe two children with virus associated hemophagocytic lymphohistiocytosis (VAHLH) secondary to hepatitis A infection.