Health Related Quality of Life in Patients with Side‐Effects after Antimuscarinic Treatment for Overactive Bladder

Research paper by Aram KIM, Kyu‐Sung LEE, Rangrhee JUNG, Selee NA, Joon‐chul KIM, Hyeong Gon KIM, Myung‐Soo CHOO

Indexed on: 14 Jun '16Published on: 01 May '16Published in: LUTS: Lower Urinary Tract Symptoms


Drug therapy is the mainstay of treatment for overactive bladder (OAB), but antimuscarinic agents possess side‐effects. These side‐effects decrease the patients' quality of life. We therefore assessed the impact of side‐effects on health‐related quality of life (HR‐QoL) through an analysis of EQ‐5D questionnaire.This study was designed to investigate the patients' satisfaction by quality weight of health status as affected by the side‐effects of OAB medications. Patients who had OAB symptoms lasting longer than 3 months and have experienced side‐effects after any antimuscarinic treatments filled in the EQ‐5D questionnaire. The enrolled patients had two EQ‐5D questionnaires for two different health statuses, i.e., presence or absence of side‐effects. Quality weight was calculated using the ED‐5D health status score with Korean tariff.One hundred patients were enrolled and completed the HR‐QoL questionnaire. The most prevalent side‐effect was dry mouth (61%) and 28% patients had dry mouth and constipation concurrently. Most of the patients with side‐effects tried to endure and overcome these side‐effects (79%), but 10% desired a change in medication, and 6% stopped medication altogether. The quality weight of EQ‐5D without side‐effects was 0.863, while the quality weight with side‐effects was 0.666 (P < 0.001). The VAS score was 79 in patient without side‐effects and 57 in those with side‐effects, supporting the results of quality weight assessment.Overactive bladder patients may enjoy a better quality of life if side‐effects associated with antimuscarinic therapy are fewer.