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Haworforbins A-C, new phenolics from Haworthia cymbiformis.

Research paper by Fumie F Yamasaki, Shoko S Machida, Asami A Nakata, Alfarius Eko AE Nugroho, Yusuke Y Hirasawa, Toshio T Kaneda, Osamu O Shirota, Naoyuki N Hagane, Tadayoshi T Sugizaki, Hiroshi H Morita

Indexed on: 17 Mar '12Published on: 17 Mar '12Published in: Journal of Natural Medicines



Abstract

Two new isocoumarin glucosides, haworforbins A (1) and B (2), and a new chromone, haworforbin C (3), have been isolated from Haworthia cymbiformis. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Haworforbin C (3) exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cell line.