Hair follicle signaling networks: a dermal papilla-centric approach.

Research paper by Raul R Ramos, Christian F CF Guerrero-Juarez, Maksim V MV Plikus

Indexed on: 14 Sep '13Published on: 14 Sep '13Published in: Journal of Investigative Dermatology


Functional testing of dermal papilla (DP) signaling inputs into hair follicle (HF) morphogenesis and regeneration is becoming possible with the advent of new Cre lines. Targeted deletion of the signature genes in early DP precursors has revealed significant signaling redundancy during HF morphogenesis. Furthermore, the DP lineage commitment program can be exploited for generating highly inductive DP cells to be used in HF bioengineering assays.