Green tea prevents vascular disturbs and attenuates periodontal breakdown in long-term hyperglycemia in T1D rats.

Research paper by Daniela Pereira DP Catanzaro, Ever Elias EE Mena Laura, Tania M TM Cestari, Ricardo V N RVN Arantes, Gustavo Pompermaier GP Garlet, Rumio R Taga, Gerson Francisco GF de Assis

Indexed on: 04 Mar '18Published on: 04 Mar '18Published in: Journal of Clinical Periodontology


The effects of green tea on the modulation of vascularization during the progression of spontaneous periodontitis in long-term hyperglycemia in streptozotocin induced type-1 diabetic (T1D) rats were evaluated. Wistar rats normoglycemic (NG) and T1D were divided in two control groups, which received water (NG-W and T1D-W) and two experimental groups that received green tea (NG-GT and T1D-GT). Periodontal structures were evaluated by microtomographic and histological analyzes. Number of immunostained cells for VEGF (NcVEGF+/mm) and CD31 (NcCD31+/mm), as well microvessel density (MVD) in the periodontal ligament (PDL) were evaluated. Long-term hyperglycemia in T1D-W rats induced vascular alterations in PDL with reduction of 36% in MVD, decrease of 33% in NcCD31+/mmand increase of 53% in NcVEGF+/mmConcomitantly, severe degree of periodontitis with higher reduction of bone volume and periodontal bone level were observed. In T1D-GT, green tea maintained the MVD, NcCD31+/mmand NcVEGF+/mmin the PDL like in similar to normoglycemic groups. Clinically, in T1D-GT rats, green tea reduced dental plaque accumulation and the degree of periodontitis compared to T1D-W. Daily green tea consumption has a therapeutic effect on the diabetic vascular disorder in PDL and progression of periodontitis in long-term hyperglycemia in T1D rats. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.