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Geriatric neutrophils: implications for older adults.

Research paper by Margaret H MH Crighton, Alicia A AA Puppione

Indexed on: 07 Feb '06Published on: 07 Feb '06Published in: Seminars in Oncology Nursing



Abstract

To review the intersection of immunosenescence and neutropenia, focusing on innate immunity, and implications for research and practice for neutropenic older adults with cancer.Research studies, journal articles, and web sites.Immunosenescence, age-related changes within the immune system renders older adults more vulnerable to infection. This vulnerability is magnified by cancer and its treatment. Unfortunately, there has been little consideration of immunosenescence as it relates to supportive care for this population.Studies detailing the impact of immunosenescence on neutropenia and outcomes for neutropenic older adults are necessary to advance clinical research and practice.