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Genetic Risk Score of Hemoglobin A 1c interact with Postpartum Weight Reduction on Glycemic Changes: Gene-Weight Interaction Analysis.

Research paper by Liyuan L Han, Donghui D Duan, Shuang S Zhang, Weiqin W Li, Leishen L Wang, Huikun H Liu, Junhong J Leng, Nan N Li, Xiaoyun X Shang, Gang G Hu, Lu L Qi

Indexed on: 06 Jul '18Published on: 06 Jul '18Published in: Diabetes, Obesity and Metabolism



Abstract

We aimed to investigate the interaction between genetic risk score of HbA and weight changes during and after pregnancy(postpartum weight reduction and gestational weight gain) on long-term glycemic changes in the largest cohort of women with preceding history of gestational diabetes mellitus (GDM) . This is a retrospective cohort using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. A genetic risk score was established by combining 10 HbA related single nucleotide polymorphisms (SNPs), which were identified by genome-wide association studies (GWAS). General linear regression models were applied to evaluate the interaction between HbA genetic risk score and weight changes during and after pregnancy(postpartum weight reduction and gestational weight gain) on glycemic changes. A total of 1156 women with preceding history of GDM were included in this respective cohort study. Statistical differences in pre-pregnancy weight, pre-delivery weight and postpartum weight were evidenced across different groups of postpartum weight reduction. After adjusted for covariates, statistical significance in changes of HbA % was only observed in postpartum weight reduction<5 kg/yr group (p= 0.002), and significant interaction between HbA genetic risk score and postpartum weight reduction on long-term changes of HbA was evidenced (p-interaction=0.01). In the category of postpartum weight reduction≥8kg/y group, women with a lower genetic risk score of HbA had a greater decrease of HbA . A genetic risk score of HbA interact with postpartum weight reduction on long-term changes of HbA among women with preceding history of GDM. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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