Generalized alternating stimulation: a novel method to reduce stimulus artifact in electrically evoked compound action potentials.

Research paper by Isaac I Alvarez, Angel A de la Torre, Manuel M Sainz, Cristina C Roldan, Hansjoerg H Schoesser, Philipp P Spitzer

Indexed on: 13 Jul '07Published on: 13 Jul '07Published in: Journal of Neuroscience Methods


Stimulus artifact is one of the main limitations when considering electrically evoked compound action potential for clinical applications. Alternating stimulation (average of recordings obtained with anodic-cathodic and cathodic-anodic bipolar stimulation pulses) is an effective method to reduce stimulus artifact when evoked potentials are recorded. In this paper we extend the concept of alternating stimulation by combining anodic-cathodic and cathodic-anodic recordings with a weight in general different to 0.5. We also provide an automatic method to obtain an estimation of the optimal weights. Comparison with conventional alternating, triphasic stimulation and masker-probe paradigm shows that the generalized alternating method improves the quality of electrically evoked compound action potential responses.