Fusidic acid resistance in Staphylococcus aureus nasal carriage strains in nine European countries.

Research paper by Casper D J CD den Heijer, Evelien M E EM van Bijnen, W John WJ Paget, Ellen E EE Stobberingh

Indexed on: 22 Jul '14Published on: 22 Jul '14Published in: Future microbiology


To evaluate fusidic acid resistance pheno- and geno-typically in nasal carriage Staphylococcus aureus isolated from general practice patients in nine European countries.Phenotypic fusidic acid resistance was determined by disc diffusion and MIC values, and genotypically by a PCR detecting fusA-E genes. The main analysis was performed on methicillin-susceptible S. aureus strains, because methicillin-resistant S. aureus isolates were scarce.Overall S. aureus fusidic acid resistance was low (<10%). fusC was the predominant mechanism of resistance and associations were found between resistance genes and specific spa types.S. aureus strains showed low resistance to fusidic acid, making this antibiotic an appropriate choice in the treatment of methicillin-susceptible S. aureus skin infections in general practice patients in the nine participating European countries.