Indexed on: 11 Jun '20Published on: 11 Jun '20Published in: International journal of environmental research and public health
The aim of this study was to estimate the frequency of functional gastrointestinal disorders (FGIDs) in infants aged up to 12 months according to the new ROME IV criteria defining these disorders, and to describe the management of FGIDs in France. This French non-interventional, cross-sectional, and multicenter study was conducted among private-outpatient physicians who each included four consecutive patients aged up to 12 months. The frequency of FGIDs was described using the ROME IV criteria versus clinicians' diagnosis. The characteristics of infants with and without FGID were compared, and the management of the FGIDs was described. In the 1722 infants analyzed, the following frequencies were observed according to the ROME IV criteria versus the physicians' diagnosis: regurgitation 41% versus 45%; colic 18% versus 30%; constipation 9% versus 19%; diarrhea 3% versus 8%. Of note, FGID infants were less frequently exclusively breastfeeding at the maternity hospital ( < 0.001), were introduced to cow's milk earlier after leaving the maternity hospital ( < 0.001), and more frequently had symptoms suggestive of cow's milk protein allergy ( < 0.001). Physicians frequently recommended an adapted infant formula (in 77% to 82% of cases depending on the FGID diagnosed) and prescribed a specific treatment in 51% to 66% of infants (probiotics: 35% to 64%). This real-world study confirms the high frequency of FGIDs in infants in France, and provides new information regarding the characteristics of FGID infants.