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Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza).

Research paper by Xiang-Xi XX Yi, Jia-Gang JG Deng, Cheng-Hai CH Gao, Xiao-Tao XT Hou, Fei F Li, Zhi-Ping ZP Wang, Er-Wei EW Hao, Yan Y Xie, Zheng-Cai ZC Du, Hui-Xue HX Huang, Ri-Ming RM Huang

Indexed on: 15 Aug '15Published on: 15 Aug '15Published in: Molecules (Basel, Switzerland)



Abstract

Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.