Quantcast

Formation of 1,3-diazaadamantane derivatives by the reaction of bispidine derivatives with dialdehydes

Research paper by A. I. Kuznetsov, I. M. Senan, I. O. Razenko, T. M. Serova

Indexed on: 23 Jul '15Published on: 23 Jul '15Published in: Russian Chemical Bulletin



Abstract

Heating of 3,7-di(tert-butyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one with hydro-bromic acid gave 1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one (1,5-dimethylbispidin-9-one). Condensation of this compound or 1,5-dimethylbispidin-9-ol with dialdehydes afforded new compounds containing two 1,3-diazaadamantane moieties in one molecule, which are connected either directly or through spacers.