Focal segmental glomerulosclerosis complicating solitary kidney.

Research paper by Yoshiyuki Y Oshiro, Sachio S Umena, Masatoshi M Noda

Indexed on: 09 Aug '08Published on: 09 Aug '08Published in: Clinical and Experimental Nephrology


A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but overall the nephrotic syndrome did not improve. Additional treatment with prednisolone and cyclosporine reduced proteinuria to less than 1.0 g/day. We report that combination therapy with ARB, ACEI, prednisolone, and cyclosporine was successful for FSGS complicating solitary kidney.