Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides.

Research paper by Richard J RJ Doyle, Zane Z Elfessi, Kevin K Kolman

Indexed on: 14 Jul '18Published on: 14 Jul '18Published in: American Journal of Emergency Medicine


Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide-related poisoning in the United States. Many clinical syndromes and treatment algorithms have been described for patients with anticoagulant rodenticide poisoning. We report a case of an acute ingestion of two anticoagulant rodenticides and successful reversal of coagulation parameters using 4-factor prothrombin complex concentrate in a fixed-dose approach. Copyright © 2018 Elsevier Inc. All rights reserved.