Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling.

Research paper by Despina E DE Ganella, Pushbalela P Thangaraju, Andrew J AJ Lawrence, Jee Hyun JH Kim

Indexed on: 17 Dec '14Published on: 17 Dec '14Published in: Behavioural Brain Research


We used pharmacological modulation of the mGlu5 receptor to investigate its role in the extinction of conditioned fear throughout development. In postnatal day (P) 17 rats, the positive allosteric modulator CDPPB facilitated, while the negative allosteric modulator MTEP impaired extinction. These drugs had no such effects on P24 or adult rats. These results establish a changing importance of mGlu5 in extinction of conditioned fear at distinct stages of development.