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Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin: results from a pilot study.

Research paper by Klaudia K Farkas, Anita A Bálint, Renáta R Bor, Imre I Földesi, Mónika M Szűcs, Ferenc F Nagy, Zoltán Z Szepes, Anita A Annaházi, Richárd R Róka, Tamás T Molnár

Indexed on: 30 Sep '14Published on: 30 Sep '14Published in: Expert review of gastroenterology & hepatology



Abstract

Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice.This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis.Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay.Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis.Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.

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