Extrapolation of a non-linear autoregressive model of pulmonary mechanics

Research paper by Ruby Langdon, Paul Docherty, Yeong Shiong Chiew, J. Geoffrey Chase

Indexed on: 10 Aug '16Published on: 08 Aug '16Published in: Mathematical Biosciences


For patients with acute respiratory distress syndrome (ARDS), mechanical ventilation (MV) is an essential therapy in the intensive care unit (ICU). Suboptimal PEEP levels in MV can cause ventilator induced lung injury, which is associated with increased mortality, extended ICU stay, and high cost. The ability to predict the outcome of respiratory mechanics in response to changes in PEEP would thus provide a critical advantage in personalising and improving care. Testing the potentially dangerous high pressures would not be required to assess their impact.

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