Experimental study on measles virus

Research paper by Seiji Arakawa, Jo Hoshino, Tiaki Kaneko, Takenori Sato

Indexed on: 01 Oct '60Published on: 01 Oct '60Published in: Archiv fur die gesamte Virusforschung


It was observed in 1953 and in 1955, that convalescent sera of measles taken from patients several times following the disease-days showed the formation of antibodies for neutralization and complement fixation.Sera of patients, inmates or parents who showed no symptoms of measles, showed a gradual increase in titers of neutralization and complement fixation antibodies against the mouse-adapted measles virus.Sera of 107 measles patients taken in 1956 to 1957, successively 3 to 5 times at various intervals during the course of illness were subjected to complement fixation test using antigen prepared from the mouse adapted measles virus.Out of 107 patients, 75 developed specific antibodies against measles. The appearance of the antibodies was observed mostly within 3 months after contraction and its disappearance within the period from 4 to 6 months. No difference was noted between the two sexes in regard to the rate of complement fixation, but when classified by age it was comparatively lower in the age group under 3 years as compared with that over 3 years. Similar antibody response was usually observed among members of the same family.