Quantcast

Evidence that the Sympathetic Nervous System Elicits Rapid, Coordinated and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure.

Research paper by Gregory J GJ Morton, Kenjiro K Muta, Karl J KJ Kaiyala, Jennifer M JM Rojas, Jarrad M JM Scarlett, Miles E ME Matsen, Jarrell T JT Nelson, Nikhil K NK Acharya, Francesca F Piccinini, Darko D Stefanovski, Richard N RN Bergman, Gerald J GJ Taborsky, Steven E SE Kahn, Michael W MW Schwartz

Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Diabetes



Abstract

Dynamic adjustment of insulin secretion to compensate for changes of insulin sensitivity that result from alteration of nutritional or metabolic status is a fundamental aspect of glucose homeostasis. To investigate the role of the brain in this coupling process, we used cold exposure as an experimental paradigm, since the sympathetic nervous system (SNS) helps to coordinate the major shifts of tissue glucose utilization needed to ensure that increased thermogenic needs are met. We found that in rats housed at 5°C for 28 h, glucose-induced insulin secretion declined by 50% and yet glucose tolerance did not change, owing to a doubling of insulin sensitivity. These potent effects on insulin secretion and sensitivity were fully reversed by either returning animals to room temperature for 4 h or by intravenous infusion of the α-adrenergic receptor antagonist phentolamine for only 30 min. By comparison, insulin clearance was not affected by either cold exposure or phentolamine infusion. These findings offer direct evidence of a key role for the brain, acting via the SNS, in the rapid, highly coordinated and reciprocal changes of insulin secretion and insulin sensitivity that preserve glucose homeostasis in the setting of cold exposure.