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Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells.

Research paper by David G DG Smith, Ga-lai GL Law, Benjamin S BS Murray, Robert R Pal, David D Parker, Ka-Leung KL Wong

Indexed on: 04 Jun '11Published on: 04 Jun '11Published in: Chemical Communications



Abstract

Image and spectral intensity from bicarbonate-selective europium(III) probes localised in the mitochondria of cells is modulated reversibly by variation of external pCO(2), and is suppressed by addition of the carbonic anhydrase inhibitor, acetazolomide.