Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population.

Research paper by Xiao-Hua XH Pei, Juan J He, Qiao Q Liu, Bei B Zhu, Li-Hua LH Bao, Chen-Jing CJ Yan, Jian-Qing JQ Wu, Wei-Hong WH Zhao

Indexed on: 02 Mar '12Published on: 02 Mar '12Published in: Scandinavian journal of urology and nephrology


This study aimed to evaluate the applicability of a selection of glomerular filtration rate (GFR) estimating equations based on serum creatinine (SCr) and serum cystatin C in a Chinese population.Estimated GFR values from 10 equations were compared with reference GFR (rGFR) from the (99m)Tc-DTPA renal dynamic imaging method. The study enrolled 569 Chinese participants (41.5% women, 53.5 ± 16.9 years, range 19-92 years), with mean rGFR 74.80 ± 26.10 (range 9.8-146.8 ml/min/1.73 m(2)).Bland-Altman analysis illustrated that the 95% agreement limits of all the equations surpassed the acceptable tolerance (<60 ml/min/1.73 m(2)), of which the MacIsaac equation was the closest one, reaching 71.7 ml/min/1.73 m(2). Linear regression analysis also demonstrated a consistent result. When assessed in all participants, the accuracy of the six equations reached and exceeded the acceptable level (≥70%), of which the Shanghai and MacIsaac equations gained more accuracy than others. When compared in subgroups, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), MacIsaac and Cockcroft-Gault (CG) equations were optimal for rGFR stages ≥ 90 ml/min/1.73 m(2), 30-89 ml/min/1.73 m(2) and < 30 ml/min/1.73 m(2), respectively.The results demonstrated that further improvement is needed for the selected 10 equations. Not all the cystatin C equations were superior to SCr equations. They have their own applicability at various GFR levels. At present, the CKD-EPI, MacIsaac and CG equations may be applied to evaluate GFR in normal, mild to moderate and severe kidney function, respectively.