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Evaluation of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ cytokines in HIV/HHV-8 coinfection.

Research paper by Dayvson Maurício DM da Silva, Juliana Prado JP Gonçales, José Valter Joaquim JVJ Silva Júnior, Thaísa Regina Rocha TRR Lopes, Luan Araújo LA Bezerra, Virginia Maria VM Barros de Lorena, Maria Rosângela Cunha MRC Duarte Coêlho

Indexed on: 16 Sep '20Published on: 15 Sep '20Published in: Journal of Medical Virology



Abstract

Imbalance in the immune response is one of the main pathogenic mechanisms of diseases related with HIV/HHV-8 coinfection, such as Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and the inflammatory cytokine syndrome (KICS). However, significant changes in pro- and anti-inflammatory cytokine levels may be observed in HIV/HHV-8 individuals who are negative for KS, PEL, MCD and/or KICS. In this study, serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ were assessed in 69 HIV and 48 HIV/HHV-8 individuals, all negatives for HHV-8-related diseases. The cytokines were measured by flow cytometry and analyzed by the Mann-Whitney test. The p-value < 0.05 and CI 95% were considered in all analyzes. IL-4 (p=0.0155), IL-6 (p=0.0036) and IL-10 (p=0.0036) levels were significantly higher in HIV/HHV-8 patients than in the HIV group. On the other hand, IL-2 (p=0.2295), TNF-α (p=0.1216) and IFN-γ (p=0.1178) did not differ between the groups analyzed. To our knowledge, to date, this is the first report on significant differences in the levels of IL-4 and IL-6 in HIV vs. HIV/HHV-8 individuals. Finally, these early findings are important as a prognostic tool and contribute to clarifying the HHV-8-host interaction. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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