Indexed on: 16 Sep '20Published on: 15 Sep '20Published in: Journal of Medical Virology
Imbalance in the immune response is one of the main pathogenic mechanisms of diseases related with HIV/HHV-8 coinfection, such as Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and the inflammatory cytokine syndrome (KICS). However, significant changes in pro- and anti-inflammatory cytokine levels may be observed in HIV/HHV-8 individuals who are negative for KS, PEL, MCD and/or KICS. In this study, serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ were assessed in 69 HIV and 48 HIV/HHV-8 individuals, all negatives for HHV-8-related diseases. The cytokines were measured by flow cytometry and analyzed by the Mann-Whitney test. The p-value < 0.05 and CI 95% were considered in all analyzes. IL-4 (p=0.0155), IL-6 (p=0.0036) and IL-10 (p=0.0036) levels were significantly higher in HIV/HHV-8 patients than in the HIV group. On the other hand, IL-2 (p=0.2295), TNF-α (p=0.1216) and IFN-γ (p=0.1178) did not differ between the groups analyzed. To our knowledge, to date, this is the first report on significant differences in the levels of IL-4 and IL-6 in HIV vs. HIV/HHV-8 individuals. Finally, these early findings are important as a prognostic tool and contribute to clarifying the HHV-8-host interaction. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.