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Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes.

Research paper by D D Hughes

Indexed on: 06 Sep '01Published on: 06 Sep '01Published in: Genome Biology



Abstract

Inversions and translocations distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosome replication. Within species, such rearrangements are found less frequently, except in the case of clinical isolates of human pathogens, where rearrangements are very frequent.