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Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery.

Research paper by Isurika R IR Fernando, Daniel P DP Ferris, Marco M Frasconi, Dmitry D Malin, Elena E Strekalova, M Deniz MD Yilmaz, Michael W MW Ambrogio, Mohammed M MM Algaradah, Michael P MP Hong, Xinqi X Chen, Majed S MS Nassar, Youssry Y YY Botros, Vincent L VL Cryns, J Fraser JF Stoddart

Indexed on: 31 Mar '15Published on: 31 Mar '15Published in: Nanoscale



Abstract

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.