ent-Abietane diterpenoids from Isodon rubescens var. rubescens.

Research paper by Sheng-Xiong SX Huang, Jian-Xin JX Pu, Wei-Lie WL Xiao, Li-Mei LM Li, Zhi-Ying ZY Weng, Yan Y Zhou, Quan-Bin QB Han, Shu-Lin SL Peng, Li-Sheng LS Ding, Li-Guang LG Lou, Han-Dong HD Sun

Indexed on: 19 Dec '06Published on: 19 Dec '06Published in: Phytochemistry


ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.