Enantioselective total synthesis of lycopodine.

Research paper by Hua H Yang, Rich G RG Carter, Lev N LN Zakharov

Indexed on: 28 Jun '08Published on: 28 Jun '08Published in: Journal of the American Chemical Society


The first enantioselective total synthesis of lycopodine has been completed. Key steps include a highly diastereoselective organocatalyzed cyclization of a keto sulfone to establish the key C7 and C8 stereocenters and a tandem 1,3-sulfonyl shift/intramolecular Mannich cyclization to form the tricyclic core.