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Embolic compositions

Imported: 24 Feb '17 | Published: 13 Jan '04

Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini

USPTO - Utility Patents

Abstract

Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.

Claims

1. An embolic composition comprising microspheres formed from macromers, wherein the macromers prior to crosslinking have a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups which are olefinically unsaturated groups, wherein the macromers are crosslinked via free-radical polymerization to form a hydrogel.

2. The embolic composition of claim 1, wherein the polymeric backbone comprises a polyhydroxy polymer.

3. The embolic composition of claim 1, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via the 1,2-diol or 1,3-diol groups.

4. The embolic composition of claim 3, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via cyclic acetal linkages.

5. The embolic composition of claim 1, wherein the polyhydroxy polymer comprises poly(vinyl alcohol) (PVA) and copolymers thereof.

6. The embolic composition of claim 1, wherein the macromers comprise units having the formula:

in which R is a linear or branched C

1-C

8 alkylene or a linear or branched C

1-C

12 alkane;

7. The embolic composition of claim 1, wherein the macromers further comprise pendant modifier groups.

8. The embolic composition of claim 1, further comprising an active agent.

9. The embolic composition of claim 1, wherein the hydrogel is biodegradable.

10. The embolic composition of claim 1, further comprising a contrast agent.

11. A method for embolization comprising administering the embolic composition of claim 1.

12. A method for embolization comprising administering the embolic composition of claim 6.

13. An embolic microsphere comprising a hydrogel, wherein the hydrogel is formed from macromers, wherein the macromers prior to crosslinking have a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups which are olefinically unsaturated groups, and wherein the macromers are crosslinked via free-radical polymerization to form the hydrogel.

14. The embolic microsphere of claim 13, wherein the polymeric backbone comprise a polyhydroxy polymer.

15. The embolic microsphere of claim 13, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via the 1,2-diol or 1,3-diol groups.

16. The embolic microsphere of claim 13, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via cyclic acetal linkages.

17. The embolic microsphere of claim 13, wherein the polyhydroxy polymer comprises poly(vinyl alcohol) (PVA) and copolymers thereof.

18. The embolic microsphere of claim 13, wherein the macromers comprise units having the formula:

in which R is a linear or branched C

1-C

8 alkylene or a linear or branched C

1-C

12 alkane;

19. The embolic microsphere of claim 13, wherein the macromers further comprise pendant modifier groups.