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Eliminating spiral waves pinned to an anatomical obstacle in cardiac myocytes by high-frequency stimuli.

Research paper by Akihiro A Isomura, Marcel M Hörning, Konstantin K Agladze, Kenichi K Yoshikawa

Indexed on: 05 Mar '09Published on: 05 Mar '09Published in: Physical review. E, Statistical, nonlinear, and soft matter physics



Abstract

The unpinning of spiral waves by the application of high-frequency wave trains was studied in cultured cardiac myocytes. Successful unpinning was observed when the frequency of the paced waves exceeded a critical level. The unpinning process was analyzed by a numerical simulation with a model of cardiac tissue. The mechanism of unpinning by high-frequency stimuli is discussed in terms of local entrainment failure, through a reduction of the two-dimensional spatial characteristics into one dimension.